Ned Luke was born on October 4, 1958 in Danville, Illinois, to Cindy (née Smith) and Fred Luke.[citation needed] His maternal grandfather was actor Paul Birch.
He graduated from Danville High School in 1977 where he was a bi-sport athlete and honor student. He later attended the University of Illinois in Champaign, Illinois. He has four siblings.
Luke's first major voice role was in Rover Dangerfield, where he played a sheepdog named Raffles opposite Rodney Dangerfield. He was cast as a guest star in several TV shows throughout the 1990s and early 2000s, and has appeared in about 100 television commercials featuring products such as Budweiser and Burger King.

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