Segan was born in New York City. He is the grandson of American photographer Arthur Rothstein, the nephew of musician Rob Stoner.
Segan has appeared in television programs, including Days of Our Lives, CSI: Crime Scene Investigation and House, and the voice of Henry on the Nickelodeon cartoon KaBlam!.
In 2008, Brick director Rian Johnson invited Segan to play a small role in his second film, The Brothers Bloom. In 2012, Segan had a supporting lead role in Johnson's third film, Looper. In 2013, he had a small role on Breaking Bad, as a fireman in the episode "Ozymandias", directed by Johnson. In April 2016, Johnson added Segan to the cast of Star Wars: The Last Jedi. Segan joined the cast of Johnson's Knives Out in December 2018, playing the supporting role of Trooper Wagner.

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