Mayo began playing high school basketball at Rose Hill Christian High School in Ashland, Kentucky. In Kentucky, grade schoolers can play high school basketball, and Mayo averaged 23.1 points for Rose Hill\'s varsity team while in 7th grade. In 8th grade he was just turning 13 and tallied 37 points per game and was named a first-team all-state player by the Louisville Courier-Journal. Mayo then moved to suburban Cincinnati to live with his club team coach Dwaine Barnes. (Mayo referred to him as his "grandfather" but the two aren\'t related.) Mayo enrolled at North College Hill High School in April 2003. The Cincinnati Enquirer and local television stations sent reporters to cover Mayo\'s first day of school at NCH.\n', '

Mayo was selected as Mr. Basketball of Ohio for the second consecutive season, in addition to being named Associated Press Division III Player of the Year for the second consecutive season. He averaged nearly 29 points, nine rebounds, and six assists per game. He also led his team to three consecutive AP poll titles and garnered much attention from the media, appearing in the pages of Sports Illustrated among other publications. Much like another high school star from Ohio (St. Vincent–St. Mary High School), LeBron James, Mayo drew large enough crowds to force his team into seeking larger venues to support the growing crowds, and often attracted National Basketball Association stars such as James and Carmelo Anthony to watch his games playing for the D-1 Greyhounds.\n', '

In February 2006, Mayo attracted the largest crowd to ever see a high school game in Cincinnati, Ohio when 16,202 fans watched North College Hill fall to the nation\'s number one rated team, Oak Hill Academy. Mayo had been considered a lock to make the leap straight from high school to the NBA, but the Collective Bargaining Agreement between the NBA and its players instituted a rule that a player must be at least a year out of high school before he can enter the NBA, effectively curtailing those plans. On July 5, 2006, it was reported by ESPN that he would attend USC. On July 8, however, WSAZ-TV reported that USC was only one of three colleges that Mayo was considering: the other two being Kansas State University and the University of Florida.\n', '

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