Merediz was born in Guantánamo, Cuba on February 15, 1956. She left Cuba with her family when she was five years old to Miami, Florida. Thereafter, she relocated with her family to Puerto Rico where she grew up. Merediz graduated with a bachelor's degree from Newcomb College, the former female counterpart to Tulane University in New Orleans, Louisiana.
Having made her film debut in 1984's The Brother from Another Planet, Merediz has since appeared in a number of films, including The Milagro Beanfield War (1988), City of Hope (1991), Evita (1996), Music of the Heart (1999), K-Pax (2001), Remember Me (2010), Custody (2016), Humor Me (2017), and the reprise of her 2008 Tony Award nominated Broadway role as Abuela Claudia, in the film adaptation In the Heights (2021). She also portrayed Alma Madrigal in Encanto (2021).
Her television credits, in both dramas and comedies, include recurring and guest roles in Diary of a Future President, New Amsterdam, Brooklyn Nine-Nine, Orange Is the New Black and Madam Secretary. She has been a series regular in the UK television series Bounty Hunters and the comedy Saint George, has appeared in episodes of both Law & Order and Law & Order: SVU, and appeared as herself as a judge on Throwdown with Bobby Flay.

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