Antigua was born in the Dominican Republic to a Dominican father and Dominican mother. The family moved to New York City and lived in the Bronx where he was raised. There Antigua and his two siblings received their primary and secondary education. He attended St. Raymond's High School, where he played basketball.
On Halloween night in 1988, Antigua became the victim of a drive-by shooting and was shot in the head near his left eye. He recovered from the shooting, however the doctors were unable to retrieve the slug from his head. He was back playing basketball just two months after the incident and gained media attention as the kid who'd taken a bullet to the head in a drive-by in his rough Bronx neighborhood. During this period of his life Antigua's family also went through a period of homelessness. He kept the family together while housing was secured.
He overcame these difficulties and went on to serve as student council president at his high school and played a major role in the program's New York Catholic League Championship run under head coach Gary DeCesare. As a senior, he earned All-New York City and Parade All America Second Team honors. Antigua also played on the Gauchos youth basketball team. He caught the attention of various scouts during his high school playing days and was signed with the University of Pittsburgh.

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