Farrow was raised as a Catholic and attended convent schools. She learned the Transcendental Meditation technique (TM) in 1966 at UCLA, and the next year became interested in yoga, opening a yoga institute at a former church in Boston. In 1968 Farrow, along with her sister Mia and brother Johnny, traveled with Maharishi Mahesh Yogi from New York to India, and then to the Maharishi's ashram in Rishikesh for a Transcendental Meditation teacher training course.
The Beatles arrived shortly thereafter. Farrow was dedicated to practicing the TM technique so she could become a TM teacher. She said: "I would always rush straight back to my room after lectures and meals so I could meditate. John, George and Paul would all want to sit around jamming and having a good time and I'd be flying into my room. They were all serious about what they were doing, but they just weren't as fanatical as me". She "turned into a near recluse" and "rarely came out" of her cottage. Lennon was asked to "contact her and make sure she came out more often to socialize" and he wrote the song "Dear Prudence". According to Lennon, "She'd been locked in for three weeks and was trying to reach God quicker than anyone else".
Farrow taught TM for several decades after her teacher training course in India. Among those she mentored was comedian Andy Kaufman. She returned to India for further instruction from the Maharishi in 1986 and has taught Transcendental Meditation in Florida since 1970.

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