Keisler was drafted by the New York Yankees in the 2nd round of the 1998 MLB Draft out of LSU. He had previously been drafted by the Cleveland Indians in the 40th round of the 1995 MLB Draft and the 57th round of the 1996 MLB Draft and the New York Mets in the 40th round of the 1997 MLB Draft but did not sign with either of those teams. He signed with the Yankees on June 2, 1998. He was selected as the Yankees Minor League player of the Year in 2000 when he was a combined 14-5 with a 2.85 ERA in 28 starts for Double-A Norwich and AAA Columbus.\n', '

Keisler made his Major League debut with the Yankees on September 10, 2000 against the Boston Red Sox, starting and pitching five innings to earn the win while allowing only one earned run. He appeared in 3 more games for the Yankees in 2000 out of the bullpen and then started 10 games for them in 2001. In his two seasons of part-time work he was 2-2 with a 7.19 ERA. He then missed the entire 2002 season while recovering from shoulder surgery he underwent in late 2001. In May 2002, Keisler, already on rehab with the shoulder injury, suffered a strange injury. While gardening, Keisler was bitten by a pygmy rattlesnake in his backyard. The Yankees released him in February, 2003.\n', '

Keisler signed as a free agent with the San Diego Padres on February 16, 2003 and made two starts with the Padres, while also appearing in 8 games (6 starts) for the AAA Portland Beavers. The Padres released him on June 5, 2003.\n', '

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