Rebecka was born in the town of Turinge, Sweden to an 18-year-old Swedish mother Kristina, and a 24-year-old Finnish father, Jyrki. Her parents divorced when she was one year old. As a child, she acted at Vår teater, a children's theatre in Stockholm. At the age of nine, Liljeberg won a role in the series Sunes jul. Between 1993 and 1997, she continued in amateur theatre until landing a role in the film Närkontakt later in 1997. The following year, she got her breakthrough in the Lukas Moodysson film Show Me Love (Fucking Åmål) (1998). She quit high school to make the film, which ultimately won her the 1999 Guldbagge Awards for best actress, together with Alexandra Dahlström.
After her roles in Fucking Åmål and Sherdil, Liljeberg began an adult education course in order to graduate from high school. While studying, she also starred in the relatively successful arthouse film Bear's Kiss which was her first and only English-speaking film and dubbed a character in the Swedish version of the IMAX 3D movie T-Rex: Back to the Cretaceous. In 2002, she completed the adult education course, and went on to study medicine at the Karolinska Institutet in Stockholm, one of the largest medical universities in Europe.
Liljeberg stopped acting after her film Bear's Kiss (2002) and now works as a doctor after completing her residency at Södersjukhuset in Stockholm. She lives in Stockholm.

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