Brothers played baseball for Lipscomb University. In 2007, he was named conference Freshman of the Year. As a sophomore in 2008, he helped the team make its first ever NCAA Tournament appearance. The following season, he had a school-record 132 strikeouts.\n', '

Brothers was drafted by the Colorado Rockies in the first round of the 2009 amateur draft, and he signed with the team on July 9. He then spent the 2009 and 2010 seasons in the minor leagues. In 2011, Brothers made his major league debut with the Rockies on June 6. He finished the season with a 1–2 win–loss record, a 2.88 earned run average (ERA), and 59 strikeouts in 40.2 innings in the majors. In 2012, he went 8–2 with a 3.86 ERA and 83 strikeouts in 67.2 innings.\n', '

On June 14, 2014, in a 5–4 win over the San Francisco Giants, Brothers became the 71st pitcher in Major League history to strike out three batters on only nine pitches in one inning. It was also the first immaculate inning in Colorado Rockies franchise history and the first at AT&T Park. In order in the eighth inning, he faced Michael Morse, Brandon Crawford, and Gregor Blanco to strike out the side. In 2014, he went 4–6 with a 5.59 ERA and 55 strikeouts in 56.1 innings.\n', '

Return to Rex Brothers Autograph Profile