Hackford was born in Los Angeles County, California, the son of film director Taylor Hackford. He began his career in 1990, first appearing in the film Pretty Woman, where he played the uncredited role of a street junkie. Hackford appeared in films, such as Safe, Exit to Eden, Déjà Vu, I Love Your Work, Blood In, Blood Out, Treasure Island, Sherrybaby and Strange Days. He played the role of Detective King in the 2006 film Stay Alive. Hackford also played the role of Grayden Nash in the 2010 film Jonah Hex.
In his television career, Hackford guest-starred in series including When Nature Calls with Helen Mirren, American Crime Story, Togetherness, Memphis Beat, Underground and True Detective. He played the recurring role of Toby in the drama television series Treme. Hackford also was the portrayer of IG-11, in which the character was voiced by Taika Waititi. His last credit was from the biographical drama miniseries Pam & Tommy, where he played the role of a manager.
Hackford owned clubs in New Orleans including One-Eyed Jacks, El Matador and Pal's Lounge.

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