Mattheus was selected by the Colorado Rockies in the 19th round of the 2003 Major League Baseball draft.\n', '

In 2004, he went 3–3, with a 4.94 ERA in 7 games, all for starts for Rookie-level Casper Ghosts in his pro debut. In 2005, he went 7–6, with a 5.82 ERA with 102 strikeouts against 52 walks in 23 games/starts for Asheville. He recorded a 4–5 record, with a 5.73 ERA in 12 home games and a 3–1 mark with 5.92 ERA in 11 road contests. He tossed a 2005 season-high ​8 1⁄3 innings in his last outing of the season on September 5 at Hickory in a 5–1 win. In 2006, he ranked 3rd among the California League Leaders in innings pitched. Mattheus was among the club leaders, ranked first in starts with 28, innings with 156 and losses with 12. He was second in wins with 7, and third in strikeouts with 131. He tossed 9 quality starts, allowed 3 runs or less in 15 outings and threw six or more innings in 13 contests. He pitched a complete game shutout on May 28 against the San Jose Giants, retiring 23 of 32 batters faced in the Nuts\' 4–0 victory. He struck out season-high 10 batters on August 17 vs. Stockton.\n', '

Mattheus went 9–11 with a 5.56 ERA in 26 games/starts in his first season at the Double-A level in 2007. He led the Texas League in runs with 100 and earned runs with 98. Also, 12 of his 26 outings were quality starts. He tossed seven or more innings on 10 occasions and registered a season-best 10 strikeouts over seven innings on August 8 against the Frisco RoughRiders. Mattheus was a Texas League All-Star in 2007, an all-star for the first time in his career. He repeated as a Texas League All-Star in 2008. That same year, he also appeared in the 2008 All-Star Futures Game at Yankee Stadium.\n', '

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