Wu was born and raised in Ann Arbor, Michigan. Their parents immigrated to the United States from China. Wu attended high school at Greenhills School and played on the basketball team. They first became interested in comedy at age 16 after watching Gabriel Iglesias' Hot and Fluffy special and began performing stand-up at high school talent shows.
They continued to perform stand-up comedy as an undergraduate student at Harvard University and were co-president of the Harvard College Stand-Up Society. Wu took one semester off to intern for The Daily Show. They graduated with a degree in psychology in 2020.
Wu's first screenwriting job was as a staff writer for the first season of the Disney+ series Doogie Kameāloha, M.D. They performed a stand-up set on The Tonight Show in 2022.

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