Senusret III was the son of Senusret II and Khenemetneferhedjet I, also called Khenemetneferhedjet I Weret (the elder). Three wives of Senusret III are known for certain. These are Itakayt, Khenemetneferhedjet II and Neferthenut, all three mainly known from their burials next to the pyramid of the king at Dahshur. Several daughters are known, although they also are attested only by the burials around the king's pyramid and their exact relation to the king is disputable. These include Sithathor, Menet, Senetsenebtysy, and Meret. Amenemhat III was most likely a son of the king. Other sons are not known.
Senusret III cleared a navigable canal through the first cataract of the Nile River, (this was different from the Canal of the Pharaohs, which apparently, Senusret III also tried to build). He also relentlessly pushed his kingdom's expansion into Nubia (from 1866 to 1863 BC) where he erected massive river forts including Buhen, Semna, Shalfak and Toshka at Uronarti.
He carried out at least four major campaigns into Nubia in his Years 8, 10, 16, and 19. His Year 8 stela at Semna documents his victories against the Nubians, through which he is thought to have made safe the southern frontier, preventing further incursions into Egypt. Another great stela from Semna dated to the third month of Year 16 of his reign mentions his military activities against both Nubia and Canaan. In it, he admonished his future successors to maintain the new border that he had created:

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