Mitre is of Mexican American descent. He grew up in Tijuana, Mexico, where he trained in the arts of kenpo, boxing and wrestling due to frequent street fights.\n', '

Mitre graduated from Montgomery High School in San Diego, California in June 1999. He and his wife, Tonya, have a son named Sam (Sergio Armando Mitre III), who was born on December 29, 2006. They also have a young daughter named Senya.\n', '

Mitre was the Chicago Cubs 7th-round selection in the 2001 Major League Baseball Draft out of San Diego City College. He was the second player out of the 2001 draft to make it to the majors with the Cubs, the first being Mark Prior. Mitre made his major league debut for the Cubs in 2003 after being called up from the West Tenn Diamond Jaxx (at the time, West Tenn was the Cubs\' Double-A affiliate). He played in 3 games in 2003 (2 starts) and had an 0-1 record with an 8.31 ERA.\n', '

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