Santos, who is of Mexican American descent, was drafted out of Mater Dei High School in Santa Ana, California by the Arizona Diamondbacks in the first round of the 2002 Major League Baseball Draft. Between 2002 and 2005, Santos steadily worked his way up through the Diamondbacks\' farm system all the way to Triple-A Tucson, where he hit 21 doubles and 12 home runs in 2005.\n', '

On December 27, 2005, Santos was sent to Toronto Blue Jays along with Troy Glaus in exchange for Miguel Batista and Orlando Hudson. In 2006, he hit .214 with 5 home runs and 38 RBI in 128 games with Toronto\'s Triple-A affiliate, the Syracuse Chiefs. He attended the Blue Jays\' 2007 spring training, but did not make the active 25-man roster. After his struggles at Triple-A Syracuse in 2006, Toronto assigned Santos to their Double-A affiliate, the New Hampshire Fisher Cats for the 2007 season. Santos won the Home Run Derby preceding the Eastern League All Star game in 2007 at Dodd Stadium.\n', '

On May 13, 2008, Santos was claimed off waivers by the Minnesota Twins. He became a free agent at the end of the season and signed a minor league contract with the Chicago White Sox, but on March 20, 2009, was traded to the San Francisco Giants in exchange for future considerations. Less than two weeks after the trade he was brought back to the White Sox organization and sent to extended spring training to convert from infielder to pitcher.\n', '

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