After attending Iowa State University, Sedlacek was drafted by the Kansas City Royals in the 14th round of the 1998 Major League Baseball Draft. He began his minor league career pitching for the Spokane Indians of the single-A (short season) Northwest League. In 16 games (13 starts), he had a 9–2 record (tying for the league lead in wins with Chris Mears), a 3.45 earned run average (ERA) (fifth), 62 strikeouts, and 18 walks in 86 innings pitched (third behind Mears\'s ​98 2⁄3 and Jeff Hundley\'s ​92 2⁄3).\n', '

In 1999, Sedlacek pitched for the Wilmington Blue Rocks of the single-A advanced Carolina League. In 17 starts, he had a 4–6 record, a 5.28 ERA, 69 strikeouts, and 26 walks in 92 innings pitched. He was promoted to the Wichita Wranglers of the double-A Texas League in 2000. In 35 games, he had a 3.66 ERA, 81 strikeouts, and 43 walks in ​140 1⁄3 innings pitched (10th in the league). Despite only making 16 starts, he led the league with 15 wins.\n', '

Sedlacek split 2001 between the Wranglers and the Omaha Royals of the triple-A Pacific Coast League. In 14 starts with Wichita, he had a 6–7 record, a 3.63 ERA, 66 strikeouts, and 14 walks in ​86 2⁄3 innings. In 14 games (13 starts) for Omaha, he had a 5–4 record, a 5.00 ERA, 44 strikeouts, and 22 walks in 81 innings.\n', '

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