Castro was signed by the Padres as a free agent from the Dominican Republic in 2006. He was considered quite raw when signed, but the Padres liked his arm strength and projectability. After a poor pro debut in the Arizona Rookie League in \'07, he was one of the better pitchers in the Northwest League in 2008, then broke out with a strong campaign in the Midwest League in \'09.\n', 'Named by Baseball America the top pitching prospect and 2nd overall prospect in the Padres organization prior to the 2010 season, he spent most of the season with the San Antonio Missions of the Texas League before being promoted to Triple-A for his final 2 starts of the season.\n', 'Following the 2010 season in which he went a combined 7-7 with a 3.28 ERA across 2 minor league stops, Castro was added to the Padres\' 40 man roster to protect him from the Rule 5 draft \n', '

After struggling most of the 2011 season, on December 31, 2011, Castro, along with Pedro Hernández, were traded to the Chicago White Sox for outfielder Carlos Quentin.\n', '

On July 5, 2013, Castro made his Major League debut against the Tampa Bay Rays. He pitched three scoreless innings, giving up two hits, walked two and struck out four.\n', '

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