Niznik intended to become a geneticist before graduating magna cum laude from Duke University majoring in theater and Russian. She then attended the California Institute of the Arts. Besides Everwood, Niznik's television roles include guest roles on Dr. Quinn, Medicine Woman, Profiler, Sliders, JAG, Frasier, Epoch, Star Trek: Enterprise, Traveler, and Diagnosis: Murder, in addition to being a series regular on the mid-1990s action drama Vanishing Son and the 2007 drama Life Is Wild. She also appeared in the films Star Trek: Insurrection and Exit to Eden. After retiring from acting in 2009, Niznik focused on volunteerism.
She died in Encino, California on June 23, 2019, at the age of 52, from chronic liver disease associated with alcoholism.

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