Thyne was born on March 7, 1975 in Stoughton, Massachusetts. He lived in Brockton, Hanover, and Hanson, before his family began moving around the country.
Thyne attended East Ridge Middle School in Ridgefield, Connecticut, before moving south to attend high school in Plano, Texas. He went on to attend the USC School of Dramatic Arts, graduating in 1997. In 2001, he co-founded Theatre Junkies, a group offering workshops and professional development for actors in the Greater Los Angeles Area.
In 2013, he became engaged to model Leah Park. As of 2019, he is single.

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