Thacker was on the football, basketball, track, and wrestling teams while at West Forsyth High School in Clemmons, North Carolina. He won the 1980 Junior National Greco-Roman championship before enrolling at NC State.
In college, Thacker won the NCAA wrestling heavyweight championship in 1984. Before that he finished 6th in 1983, and 8th in 1982, making him in total a 3-time All-American. He also won four Atlantic Coast Conference titles with the Wolfpack. He finished his college career 92-11-1, ranking second in NC State history with an .889 winning percentage and 54 pins. Thacker majored in criminal justice while at NC State.
He began his film career after Clint Eastwood noticed him in Time magazine and noted the 6-foot-4 and 450-pound (1.93 m, 204 kg) Thacker's size. Thacker went on to appear in several films including City Heat, Wildcats, two of the Police Academy films, and Identity Crisis.

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