Granaderos was born in Ypsilanti, Michigan, and raised in Portage, Michigan. He later moved to Los Angeles to pursue modeling and acting. Granaderos is half-Filipino. His father is a Filipino of the Chavacano ethnic group from Zamboanga admixture. Granaderos graduated from Portage Northern High School and later attended Michigan State University, where he majored in advertising and played on the Michigan State Spartans men's soccer team.
Before beginning his acting career, he worked as a production assistant on the short film Committed. In 2016, he played Ash Franklin in the web series Tagged. He also appeared in the TV show In the Vault as Taylor Price.
Granaderos made recurring appearances in the first two seasons of 13 Reasons Why. He was promoted to series regular for season 3. Granaderos had originally auditioned for the roles of Justin Foley, Tony Padilla and Jeff Atkins, before being cast as Montgomery De La Cruz.

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