Topor is the author of the 1979 play Nuts and the screenplay for the 1987 film, which became a starring vehicle for Barbra Streisand. He also wrote the screenplay for the 1988 film, The Accused, which starred Jodie Foster. He won the Writers Guild of America Award for his screenplay for the 1990 made-for-television film, Judgment, which he also directed. In 1996 he won the Dilys Award for his novel, The Codicil.
Topor's works tend to involve courtroom drama, psychological drama, docudrama, melodrama, social problems, crime, and/or sexual abuse issues. Prior to his career as an author, he was a reporter for the New York Post, covering stories in police stations, courtrooms, hospitals, and psychiatric wards. He also did some reporting for the New York Daily News and the New York Times.
His career as a playwright began in 1969 with a series of one-act plays staged Off-Off-Broadway. This culminated in a run of his play Nuts on Broadway from April 28, 1980 into August of that year. Anne Twomey, in the lead role, received a Tony Award nomination for her performance. The play was published in 1981, and was made into a film of the same name starring Barbra Streisand and Richard Dreyfuss in 1987, with Topor himself adapting it into a screenplay.

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