Caldwell Dyson is the younger of two girls, was born in Arcadia, California, and later moved to Beaumont, California, in the early 1980s to attend junior high school where her father worked as an electrician. Her recreational interests include running, weight training, hiking, softball, basketball, and auto repair/maintenance. As an undergraduate, she competed in intercollegiate athletics on the CSUF Titans track team as both a sprinter and long jumper. She is married to Naval Aviator George Dyson. She believes in God, and was raised Methodist.[citation needed].
In a television interview on the 40th anniversary of the first Moon landing, she said she is the first astronaut who was born after Apollo 11.
As an undergraduate researcher at the California State University, Fullerton (CSUF), Caldwell Dyson designed, constructed and implemented electronics and hardware associated with a laser-ionization, time-of-flight mass spectrometer for studying atmospherically relevant gas-phase chemistry.

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