Marquez appeared in a 1992 episode of Seinfeld called "The Cheever Letters", portraying a secretary in the Cuban Permanent Mission (the US and Cuba did not have mutual embassies from 1961 to 2015). Her success with Stand and Deliver led to a career in film and television, with roles in the crime drama, Blood In Blood Out (1993), and the independent film, Twenty Bucks (1993). Her television work included guest spots on popular programs, including Melrose Place in 1994 and Malcolm & Eddie in 1999, and recurring roles on ER from 1994 to 1997. In addition to her acting credentials, Marquez appeared as a singer in the 2000 thriller film, Under Suspicion.
Vanessa Rosalia Marquez was born in Los Angeles County, California. She was the daughter of John Marquez, who died during the Vietnam War when she was one and half years old; and Delia. She grew up in Montebello, where she attended Schurr High School.
Prior to her death, Marquez made headlines related to the #MeToo movement, alleging that she endured harassment while on the set of ER. In October 2017, she accused series star George Clooney of helping to "blacklist" her after she complained to executives about the harassment. Clooney denied the allegations.

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