Williams was born in Shreveport, Louisiana. In 1986, she worked with then husband Peter Case on his debut album, following a year later with her own debut, Happy Come Home, produced by Anton Fier, with an accompanying 28 minute documentary by D. A. Pennebaker. In 1990 she released Swing the Statue. She also often appeared onstage and on record with the band Giant Sand. In 1993 she acted in Gus Van Sant\'s Even Cowgirls Get the Blues, who also made the video for "Tarbelly and Featherfoot".\n', '

In 1993, as Williams\' career was beginning to take off, she was diagnosed with multiple sclerosis. Because she did not have health insurance, an array of artists, including Pearl Jam, Lou Reed, Maria McKee, Dave Pirner, and Lucinda Williams, recorded some of Williams\' songs on CD for a benefit project called Sweet Relief: A Benefit for Victoria Williams. This led to the creation of the Sweet Relief Musicians Fund, a charity that aids professional musicians in need of health care. That year, Williams also released a new album, titled Loose. A second album, covering the songs of Vic Chesnutt, was recorded for the Sweet Relief Fund in 1996 under the title Sweet Relief II: Gravity of the Situation, and Williams performed a duet with Chesnutt on the album.\n', '

Also that year, Williams appeared on Strong Hand of Love, a fund-raising tribute album to songwriter Mark Heard, who had died in 1992. That December she participated in a Christmas concert with Jane Siberry, Holly Cole, Mary Margaret O\'Hara and Rebecca Jenkins, broadcast over CBC Radio in Canada and National Public Radio in the United States and subsequently released on CD as Count Your Blessings.\n', '

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