Spano was born in Brooklyn, New York to Italian-American parents Vincent Sr. and Theresa.
His career started when he was 14 years old in the Broadway drama The Shadow Box. He was originally credited as Vincent Stewart because his first agent felt the name Spano was "too ethnic", and he was even instructed to sign autographs using that stage name. At age 16, in respect for his Italian heritage, Spano began using his real name and has done so ever since then.
His debut in The Shadow Box was in 1977, first at the Long Wharf Theatre in New Haven, Connecticut and later on Broadway in New York City. Spano's film debut was at the age of 15 in the mystery The Double McGuffin, shot in the winter of 1978. Following The Double McGuffin, he shot Over the Edge in the summer of 1978.

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