Castillo was originally signed as an undrafted free agent in 2002 by the Arizona Diamondbacks. He first played in Arizona\'s farm system in 2004, mostly in the rookie-level Pioneer League, while also appearing in six Triple-A games. He spent 2005 playing in Class A and spent 2006 in Class A-Advanced, Double-A, and Triple-A. In 2007, he played for the Double-A Mobile BayBears where he had a .302 batting average in 109 games. In 2008, Castillo was named the 14th-best prospect in the Diamondbacks organization, and played 104 games in Triple-A for the Tucson Sidewinders of the Pacific Coast League, batting .254 with six home runs and 47 RBIs.\n', '

On August 14, 2008, Castillo was sent to the Cincinnati Reds as a part of the Adam Dunn trade, which took place August 11. On September 1, he was called up and made his MLB debut the following day against the Pittsburgh Pirates, flying out to left in his one at-bat as a pinch hitter. His first hit was on September 3, a single to right field off T. J. Beam of the Pirates, also as a pinch hitter. Castillo played in 18 MLB games in 2008, with 9 hits in 32 at-bats for a .281 average. He began the 2009 season with the Triple-A Louisville Bats after failing to earn a spot on the Reds\' roster. On June 20, he was called up to the Reds and appeared in four games with two hits in three at-bats. He played in a total of 22 games with the Reds over the two seasons, with 11 hits in 35 at-bats for a .314 average.\n', '

Following the 2010 season, Castillo became a minor league free agent. He signed a minor league contract, with an invitation to spring training, with the Atlanta Braves. He spent the 2011 season with the Triple-A Gwinnett Braves, recording a slash line of .262/.285/.366 with 5 HR and 37 RBI in 80 games.\n', '

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