Collazo graduated from Florida International University, where he went 13–1 as a senior and helped his team to the NCAA Division I Baseball Championship tournament. He was drafted by the Atlanta Braves in the 10th round of the 2001 Major League Baseball draft. Collazo played for the Braves, Los Angeles Angels, and New York Mets organizations. He was called up to the Mets on September 1, 2007, and made his major league debut on September 5, 2007, against the Cincinnati Reds. He became a free agent at the end of the 2008 season and signed a minor league contract with the Florida Marlins.
He last played in the Toronto Blue Jays organization from 2010 to 2012. Collazo was the pitching coach for the Short Season-A Vancouver Canadians in 2016. On January 19, 2017, he was promoted to be the pitching coach for the Class-A Lansing Lugnuts.
In July 2019, Collazo was named the pitching coach at FIU.

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