Mabius gained widespread recognition for his role as Daniel Meade on the ABC comedy-drama series Ugly Betty. He also appeared on the Showtime series The L Word and in the films Cruel Intentions, The Crow: Salvation, and Resident Evil.\n', '

Mabius was born in Harrisburg, Pennsylvania, the son of Elizabeth (née Dziczek) and Craig Mabius. His father worked as a historian preserving the Historic Allaire Village. He has a brother, Craig. Mabius is Roman Catholic. His mother is of Polish descent, while his father has Austrian and Irish ancestry. After attending Amherst Regional High School in Amherst, Massachusetts, where he was voted "Most Dramatic Girly" as a senior, he enrolled in Sarah Lawrence College in Bronxville, New York, where he pursued his education in film theory.\n', '

Mabius wed Ivy Sherman, an interior designer, in January 2006; the two first met in high school during a health education class. They have two sons: Maxfield Elliot was born on June 24, 2006 and Rylan Jaxson was born on December 7, 2008.\n', '

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