Prior to playing professionally, Knudson attended Bonita Vista High School and then the University of California, San Diego. During his tenure at the University, he pitched for the North Adams SteepleCats of the New England Collegiate Baseball League and he also played for the Woodstock River Bandits of the Valley Baseball League, earning an All-Star selection in 2009. He earned All-West and All-CCAA honors in 2011.\n', '

The Detroit Tigers selected Knudson in the 28th round of the 2011 Major League Baseball Draft and he pitched for the GCL Tigers and Connecticut Tigers that year, posting a 3.42 ERA in 18 games. In 2012, he had a 3.86 ERA in 16 games between the Lakeland Flying Tigers and West Michigan Whitecaps and in 2013, he had a 1.79 ERA in 42 games for the Whitecaps. Between Lakeland and the Erie SeaWolves in 2014, he had a 3.99 ERA with seven saves in 40 appearances. One observer noted he has a "slider that is about MLB average" and that he "may cut out an MLB career for himself."\n', '

On August 20, 2015, the Tigers purchased the contract of Knudson from the Toledo Mud Hens after placing starters Anibal Sánchez and Daniel Norris on the disabled list. Prior to being called up by the Tigers, Knudson had a 1–2 record and a 2.52 ERA in 30 appearances with the Mud Hens, allowing 27 hits over 39​1⁄3 innings, with 21 walks and 40 strikeouts. Knudson made his major league debut on August 22, in a game against the Texas Rangers. In his debut, he pitched one inning, allowing one hit, a home run to Rougned Odor, with two strikeouts and no walks. Knudson became the first pitcher since at least 1914 to give up a home run in each of his first four Major League relief appearances.\n', '

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