Harris won a Tony Award in 2002 as a Featured Actress in a Musical for her performance in Thoroughly Modern Millie. In addition to television and theater, she has made various film appearances, including Memento, Addams Family Values, Nurse Betty and Phantom Thread.
Harris was born in Fort Worth, Texas, one of two daughters. On her mother's side, she is a descendant of one of the brothers of Marion Sansom, a 20th-century rancher and civic leader. Sansom Park is named after him. She began acting as a youngster, attending Arlington Heights High School. She attended Fort Worth Country Day School and graduated from there in 1973. At age 17, she was accepted at the Juilliard School's Drama Division (1973–77, Group 6) where she earned a Bachelor of Fine Arts degree.
After graduation from Juilliard, she joined John Houseman's touring repertory company The Acting Company, where she stayed for three years. During this time, she performed in productions of Shakespeare's King Lear and Romeo and Juliet, Antigone, and Mother Courage and Her Children.

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