Danning was born in Los Angeles and was Jewish. He was nicknamed "Harry The Horse" for Damon Runyon\'s Broadway character. He attended Los Angeles High School in Los Angeles. His brother, Ike Danning, played for the St. Louis Browns in 1928.\n', '

Danning first played with the New York Giants in 1933. From 1934 to 1936, he served as the Giants reserve catcher, working behind Gus Mancuso. In 1934 in spring training, despite a team reservation Jewish ballplayers Phil Weintraub and Danning were refused entry to the Flamingo Hotel in Miami Beach, Florida, which had a "No Jews" policy. However, they were allowed to stay when Giants manager Bill Terry threatened he would take the whole team to another hotel if his Jewish ballplayers were not allowed in.\n', '

In the 1937 season, Danning and Mancuso shared the catching duties with Danning appearing in 93 games, while Mancuso appeared in 86 games. In 1938 Danning took over the role as the Giants starting catcher. He was selected for the National League All-Star squad in four consecutive years (1938–41), was on the world champion Giants team which defeated the Washington Senators in the 1933 World Series, and appeared in the pennant-winning clubs that were defeated by the New York Yankees in the 1936 and 1937 World Series.\n', '

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