He was born in Thiès and studied in Paris as well as at Princeton University. He joined the PDS when he was 15 years old and was Wade's campaign director in the February 1988 presidential election.
Seck served as Minister of Trade, Crafts, and Industrialization as an opposition member of Abdou Diouf's government. He became deputy leader of the PDS in 1998, replacing Ousmane Ngom. After Wade took office in April 2000, he appointed Seck as Minister of State and Director of the Cabinet. The PDS was restructured after this election; Seck's position of Executive Secretary was eliminated and he instead became Deputy National Secretary. He also became Mayor of Thiès.
Seck was appointed as prime minister by Wade on November 4, 2002, replacing Mame Madior Boye; this was the first time that Wade had appointed a prime minister from the PDS since he took office as president. Seck served as Prime Minister until July 21, 2004, when he was dismissed by Wade.

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