He was born in Seattle in 1928 and studied at the University of Southern California from which he received his B.A. in 1948.
Garfinkle was one of the co-creators with director Cary Brown and fellow screenwriter Francis Feighan of the Collaborator, an interactive scriptwriting computer program that was popular in the 1990s. Garfinkle's obituary in the Los Angeles Times stated that Collaborator "poses questions aimed at shaping a movie treatment and prods the writer to flesh out characters".
Garfinkle also co-wrote the story for the 1973 Broadway musical Molly that starred Kaye Ballard.

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