Astin was born on May 12, 1973, in Los Angeles, California, the son of actress Patty Duke and actor John Astin. His brother is actor Sean Astin. He attended Ralph Waldo Emerson Middle School and University High School in Los Angeles. He is married to Jennifer Abbott Astin (née Bautz).
Astin made his acting debut at age 9 in the TV movie Lois Gibbs and the Love Canal, but is probably best remembered for his television role as Andy Moffett over four seasons from 1985 to 1988 on the sitcom The Facts of Life. He has had recurring roles on Scandal, The Magicians, and Homeland, and has made guest appearances on LOST, House, Psych, Grey's Anatomy, and NCIS.

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